Endocrine Abstracts

Introduction: Weight gain and obesity promote metabolic syndrome, diabetes and other cardiovascular risk factors. Weight loss achieved by lifestyle change can limit progression of cardiovascular risk factors. What is the current approach to obesity in general practice and can a nurse- led programme result in clinically beneficial weight change?Methods: The Counterweight Programme has developed a model of best practice for obesity management in UK primary...

The Sheffield Children’s Diabetes Team [SCDT] look after approximately 240 patients with Type 1 Diabetes aged 0–17 years. We have approximately 35 newly diagnosed patients each year and the level of social deprivation amongst our clinic population is high. Historically the team has always performed well in terms of measured outcomes and in the 2014–2015 National Paediatric Diabetes Audit [NPDA] data we ranked amongst the top five units in the country with a mean...

Background: National Paediatric Diabetes Audit report 2012–2013 showed an increase in the number of patients with HbA1C >80 mmol/l at our paediatric diabetes unit.Aim: Two methods of intensive support for patients with high HbA1C were trialled- monthly clinics and weekly telephone contact.Method: From January to June 2014 we offered monthly ‘Target’ clinic appointments to a cohort of ten patients with high HbA1C....

Introduction: Increasing evidence shows that type 2 diabetes mellitus (T2DM) could be reversible and that this is related to weight loss. Significant weight loss achieved through bariatric surgery or medically can result in diabetes remission. Diabetes remission is more likely to occur in those who are younger, have shorter duration of disease, and are on fewer diabetes medications. The impact of using a low energy formula-based diet in combination with physical activity on T2...

Introduction: Type 2 Diabetes Mellitus (T2DM) and obesity are a serious health challenge. Obesity and metabolic disorders are associated with cardiovascular risk. Several studies have suggested that low vitamin D status contributes to insulin resistance. This study aimed to explore vitamin D and its relationship with cardio-metabolic risk factors in those with early T2DM.Methods: Early T2DM subjects (N=139) with early T2DM, ≤ 3 years, were...

Thyroid function changes with advancing age, however there is little good quality data available that characterises the extent of thyroid disease in the elderly, or the parameters of normal thyroid function in the ‘oldest old’. Reference ranges for serum TSH and free thyroid hormones based on unselected younger adults are currently applied uniformly to older individuals.The Newcastle 85+ study has collected health and lifestyle information from...

Introduction: The global migration of healthcare professionals has enabled those trained in low-and-middle income countries (LMICs) to move and work in high-income countries (HICs) and vice-versa. While medical licensing exams in HICs are designed to assess competency of the immigrating HCPs, there is limited literature on the differences in approach to manage clinical cases between those from LMIC and HIC. Simulation via Instant Messaging – Birmingham Advance (SIMBA) is ...

Aim: The sex hormones initiate profound physical and physiological changes during early puberty, but to what extent are they responsible for continuing the body composition changes of late adolescence? We aimed to examine the effect on body composition of sudden sex hormone withdrawal to gain insight into their action.Patients and Methods: Thirty six healthy phenotypically and chromosomally normal postpubertal individuals aged 15–17 years with gende...

Background: Chromosome analysis is always indicated in disorders of sex development (DSD), but the need for karyotyping in gender dysphoria (GD) is less clear.Aims and objectives: We therefore aimed to review the place of routine chromosome analysis in the management of GD in children and adolescents.Patients and methods: Five hundred and twenty children and adolescents with GD have been referred at the time of reporting to the two...

Introduction: T2DM (type 2 diabetes mellitus) appears to worsen the course of NAFLD (Non-Alcoholic Fatty Liver Disease) and NAFLD can make diabetes management more challenging. Long-term, NAFLD can lead to liver fibrosis, steatohepatitis, cirrhosis, and end-stage liver disease. This study aimed to examine factors associated with NAFLD measures in early T2DM.Methods: Subjects (n=144) with early T2DM (<=3 years) and obesity (BMI>=27 kg/m<s...